Mucin biosynthesis: Molecular cloning and expression of mouse mucus-type core 2 β1,6 N-acetylglucosaminyltransferase
نویسندگان
چکیده
Mitsuyoshi Hashimoto2,3, Shuhua Tan3, Naoyoshi Mori2, Helen Cheng3, and Pi-Wan Cheng1,3,4 2Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center and 4Eppley Cancer Center for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA
منابع مشابه
Mucin biosynthesis: molecular cloning and expression of mouse mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase.
Secreted mucins protect the underlying epithelium by serving as the major determinant of the rheological property of mucus secretion and the receptors for pathogens. These functions can be affected by the three branch structures, including core 2, core 4, and blood group I, which are synthesized by the mucus-type core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT-M). Decreased activity of th...
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Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, α1,4-N-acetylg...
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